Importin Beta
نویسندگان
چکیده
منابع مشابه
The Ketel gene encodes a Drosophila homologue of importin-beta.
The Drosophila melanogaster Ketel gene was identified via the Ketel(D) dominant female sterile mutations and their ketel(r) revertant alleles that are recessive zygotic lethals. The maternally acting Ketel(D) mutations inhibit cleavage nuclei formation. We cloned the Ketel gene on the basis of a common breakpoint in 38E1. 2-3 in four ketel(r) alleles. The Ketel(+) transgenes rescue ketel(r)-ass...
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The beta-karyopherin/RanGTP system constitutes the largest known family of cellular cargo transporters. The flexibility of the karyopherin transport receptors is the key to their versatility in binding cargoes of different shape and size. Despite strong binding of the Ran complex, the comparably low energy associated with GTP hydrolysis suffices to drive dissociation and fuel the transport cycl...
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The vertebrate glucocorticoid receptor (GR) is cytoplasmic without hormone and localizes to the nucleus after hormone binding. GR has two nuclear localization signals (NLS): NL1 is similar in sequence to the SV40 NLS; NL2 is poorly defined, residing in the ligand-binding domain. We found that GR displayed similar hormone-regulated compartmentalization in Saccharomyces cerevisiae and required th...
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The retroviral Gag polyprotein orchestrates the assembly and release of virus particles from infected cells. We previously reported that nuclear transport of the Rous sarcoma virus (RSV) Gag protein is intrinsic to the virus assembly pathway. To identify cis- and trans-acting factors governing nucleocytoplasmic trafficking, we developed novel vectors to express regions of Gag in Saccharomyces c...
متن کاملImportin beta negatively regulates nuclear membrane fusion and nuclear pore complex assembly.
Assembly of a eukaryotic nucleus involves three distinct events: membrane recruitment, fusion to form a double nuclear membrane, and nuclear pore complex (NPC) assembly. We report that importin beta negatively regulates two of these events, membrane fusion and NPC assembly. When excess importin beta is added to a full Xenopus nuclear reconstitution reaction, vesicles are recruited to chromatin ...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2004
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2004.10.026